Ian Lewkowich PhD, Assistant Professor

Immunology
Cincinnati Children’s Hospital Medical Center

E-Mail: ian.lewkowich(at)cchmc.org
Tel.: 001 513 636 3999

Recent publications:

1: Quell, K. M., Dutta, K., Korkmaz, Ü. R., Nogueira de Almeida, L., Vollbrandt, T., König, P., Lewkowich, I., Deepe, G. S. Jr., Vershoor, A., Köhl, J., Laumonnier, Y. GM-CSF and IL-33 Orchestrate Polynucleation and Polyploidy of Resident Murine Alveolar Macrophages in a Murine Model of Allergic Asthma. Int. J. Mol. Sci. 2020, 21, 7487. PMID: 33050608

2: McAlees JW, Lajoie S, Dienger K, Sproles AA, Richgels PK, Yang Y, Khodoun M,Azuma M, Yagita H, Fulkerson PC, Wills-Karp M, Lewkowich IP. Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma. Eur J Immunol. 2015 Apr;45(4):1019-29. PubMed PMID: 25630305.

3: Yang D, Sun YY, Bhaumik SK, Li Y, Baumann JM, Lin X, Zhang Y, Lin SH, Dunn RS,Liu CY, Shie FS, Lee YH, Wills-Karp M, Chougnet CA, Kallapur SG, Lewkowich IP, Lindquist DM, Murali-Krishna K, Kuan CY. Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns. J Neurosci. 2014 Dec 3;34(49):16467-81. PubMed PMID: 25471584.

4: Lewkowich IP, Lajoie S, Stoffers SL, Suzuki Y, Richgels PK, Dienger K, SprolesAA, Yagita H, Hamid Q, Wills-Karp M. PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production. Mucosal Immunol. 2013Jul;6(4):728-39. PubMed PMID:23149662.

5: Hung LY, Lewkowich IP, Dawson LA, Downey J, Yang Y, Smith DE, Herbert DR. IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):282-7. PubMed PMID: 23248269.

6: Lutfi R, Lewkowich IP, Zhou P, Ledford JR, Page K. The role of protease-activated receptor-2 on pulmonary neutrophils in the innate immune response to cockroach allergen. J Inflamm (Lond). 2012 Sep 6;9(1):32. PubMed PMID: 22954301.

7: Lutfi R, Ledford JR, Zhou P, Lewkowich IP, Page K. Dendritic cell-derived tumor necrosis factor a modifies airway epithelial cell responses. J InnateImmun. 2012;4(5-6):542-52. PubMed PMID:22517116.

8: Day SB, Ledford JR, Zhou P, Lewkowich IP, Page K. German cockroach proteases and protease-activated receptor-2 regulate chemokine production and dendritic cell recruitment. J Innate Immun. 2012;4(1):100-10. PubMed PMID: 21876326.

9: Lewkowich IP, Day SB, Ledford JR, Zhou P, Dienger K, Wills-Karp M, Page K. Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation. Respir Res. 2011 Sep 21;12:122. PubMed PMID: 21936897.

10: Page K, Zhou P, Ledford JR, Day SB, Lutfi R, Dienger K, Lewkowich IP. Early immunological response to German cockroach frass exposure induces a Th2/Th17 environment. J Innate Immun. 2011;3(2):167-79. PubMed PMID: 21051864.

11: Lajoie S, Lewkowich IP, Suzuki Y, Clark JR, Sproles AA, Dienger K, BudelskyAL, Wills-Karp M. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nat Immunol.2010 Oct;11(10):928-35. PubMed PMID:20802484.

See all publications on PubMed