Dr. rer. nat Christoph Hölscher

Dept. of Molecular Infectiology,
Research Center Borstel

E-Mail: choelscher(at)fz-borstel.de
Tel.: 0049 4537 188 5860

Recent publications:

1. Böhme J, Roßnagel C, Jacobs T, Behrends J, Hölscher C, Erdmann H. Epstein-Barrvirus-induced gene 3 suppresses T helper type 1, type 17 and type 2 immune responses after Trypanosoma cruzi infection and inhibits parasite replication by interfering with alternative macrophage activation. Immunology. 2016Mar;147(3):338-48. PubMed PMID: 26694585.

2. Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, PelczarP, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H. IL-23 promotes immunopathology and prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-inducedliver damage. J Hepatol. 2016 Jan 22. PubMed PMID: 26809113.

3. Speer A, Sun J, Danilchanka O, Meikle V, Rowland JL, Walter K, Buck BR, Pavlenok M, Hölscher C, Ehrt S, Niederweis M. Surface hydrolysis of sphingomyelinby the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages. Mol Microbiol. 2015 Sep;97(5):881-97.  PubMed PMID: 26036301.

4. Hernández PP, Mahlakõiv T, Yang I, Schwierzeck V, Nguyen N, Guendel F, Gronke K, Ryffel B, Hölscher C, Dumoutier L, Renauld JC, Suerbaum S, Staeheli P,Diefenbach A. Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection. Nat Immunol. 2015 Jul;16(7):698-707. PubMed PMID: 26006013.

5. Lunding LP, Webering S, Vock C, Behrends J, Wagner C, Hölscher C, Fehrenbach H, Wegmann M. Poly(inosinic-cytidylic) acid-triggered exacerbation of experimental asthma depends on IL-17A produced by NK cells. J Immunol. 2015 Jun15;194(12):5615-25. PubMed PMID:25972482.

6: Heitmann L, Abad Dar M, Schreiber T, Erdmann H, Behrends J, Mckenzie AN, Brombacher F, Ehlers S, Hölscher C. The IL-13/IL-4Rα axis is involved in tuberculosis-associated pathology. J Pathol. 2014 Nov;234(3):338-50. PubMed PMID: 24979482.

7: Maiwald F, Benítez D, Charquero D, Dar MA, Erdmann H, Preu L, Koch O, Hölscher C, Loaëc N, Meijer L, Comini MA, Kunick C. 9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma. Eur J Med Chem. 2014 Aug 18;83:274-83. PubMed PMID: 24973661.

8: Berod L, Stüve P, Varela F, Behrends J, Swallow M, Kruse F, Krull F, Ghorbani P, Mayer CT, Hölscher C, Sparwasser T. Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity. PLoS One. 2014 Jul 22;9(7):e102804. eCollection 2014. PubMed PMID: 25050936.

9: Erdmann H, Roßnagel C, Böhme J, Iwakura Y, Jacobs T, Schaible UE, Hölscher C. IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment. Immunobiology. 2013Jun;218(6):910-23. PubMed PMID: 23182712.

10: Heitmann L, Schoenen H, Ehlers S, Lang R, Hölscher C. Mincle is not essential for controlling Mycobacterium tuberculosis infection. Immunobiology. 2013Apr;218(4):506-16. PubMed PMID: 22784441.

See all publications on PubMed