Edith Janssen, PhD, Assistant Professor

Division of Cellular and Molecular Immunology
Cincinnati Children’s Hospital Medical Center

E-Mail: edith.janssen(at)cchmc.org
Tel.: 001 513 636 4200

Recent publications:

1. Legein B, Janssen EM, Theelen TL, Gijbels MJ, Walraven J, Klarquist JS,Hennies CM, Wouters K, Seijkens TT, Wijnands E, Sluimer JC, Lutgens E, Zenke M,Hildner K, Biessen EA, Temmerman L. Ablation of CD8α(+) dendritic cell mediatedcross-presentation does not impact atherosclerosis in hyperlipidemic mice. SciRep. 2015 Oct 21;5:15414. PubMed PMID: 26486587.

2. Chougnet CA, Thacker RI, Shehata HM, Hennies CM, Lehn MA, Lages CS, Janssen EM. Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging DendriticCells Is Associated with Mitochondrial Dysfunction. J Immunol. 2015 Sep15;195(6):2624-32. PubMed PMID:26246142.

3. Hennies CM, Lehn MA, Janssen EM. Quantitating MHC class II trafficking inprimary dendritic cells using imaging flow cytometry. J Immunol Methods. 2015Aug;423:18-28. PubMed PMID:25967952.

4: Klarquist J, Hennies CM, Lehn MA, Reboulet RA, Feau S, Janssen EM. STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells. J Immunol. 2014 Dec 15;193(12):6124-34. PubMed PMID: 25385820.

5: Zhang X, Ulm A, Somineni HK, Oh S, Weirauch MT, Zhang HX, Chen X, Lehn MA, Janssen EM, Ji H. DNA methylation dynamics during ex vivo differentiation and maturation of human dendritic cells. Epigenetics Chromatin. 2014 Aug 20;7:21. PubMed PMID: 25161698.


6: Klarquist JS, Janssen EM. Melanoma-infiltrating dendritic cells: Limitations and opportunities of mouse models. Oncoimmunology. 2012 Dec 1;1(9):1584-1593. PubMed PMID: 23264904.

7: Wolkers MC, Gerlach C, Arens R, Janssen EM, Fitzgerald P, Schumacher TN, Medema JP, Green DR, Schoenberger SP. Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression. Blood. 2012 Jan 19;119(3):798-804. PubMed PMID: 22128144.

8: Thacker RI, Janssen EM. Cross-presentation of cell-associated antigens by mouse splenic dendritic cell populations. Front Immunol. 2012 Mar 14;3:41. PubMed PMID: 22566924.

9: Nierkens S, den Brok MH, Garcia Z, Togher S, Wagenaars J, Wassink M, Boon L, Ruers TJ, Figdor CG, Schoenberger SP, Adema GJ, Janssen EM. Immune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cells. Cancer Res. 2011 Oct 15;71(20):6428-37. PubMed PMID: 21788345.

10: Wolkers MC, Bensinger SJ, Green DR, Schoenberger SP, Janssen EM. Interleukin-2 rescues helpless effector CD8+ T cells by diminishing the susceptibility to TRAIL mediated death. Immunol Lett. 2011 Sep 30;139(1-2):25-32. PubMed PMID: 21621553.

See all Publications on PubMed