First Generation - Project Area B // Immunoregulation of infection-driven inflammation

The main goal of the eight projects that form research area B in the first generation was to broaden our understanding of underlying pathogen sensing, activation and modulation of innate immune cells, its impact on the development of pathogen-specific adaptive immunity and, eventually, the resolution of the immune response.

Project B1 investigated novel pathways of T.gondii sensing by the pairing of two G-protein-coupled receptors.

Project B2 deals with the role of C5aR as a novel determinant of Natural Killer (NK) cell control of T.gondii infection.

Project B3 focused on the modulation of DC functions by PNACs from stressed or damaged cells and its impact on L. major infection.

Project B4 focused on the role of lipid mediators in neutrophil- mediated clearance of apoptotic cells in L. major infection.

Project B6 determined the impact of age on regulator T cell-modulated vaccination against Mtb infection.

Project B7 dealt with pathogen-derived lipid mediators in Mtb infection.

Project B8 focused on the functional relevance of HIF-1 for granuloma formation in Histoplasmosis.

First Generation - Research Area B