Latest Publications

 

2021 

 

Wenzel U., Kemper C., Köhl J. Canonical and non-canonical functions of the complement system in health and disease. Br. J. Pharmacol. 2021. Jul;178(14):2751-2753. doi: 10.1111/bph.15503. PMID: 34159599.

 

Nording, H., Baron, L., Haberthür, D., Emschermann, F., Mezger, M., Sauter, M., Sauter, R., Patzelt, J., Knoepp, K., Nording, A., Meusel, M., Meyer-Saraei, R., Hlushchuk, R., Sedding, D., Borst, O., Eitel, I., Karsten, C.M., Feil, R., Pichler, B., Erdmann, J., Verschoor, A., Chavakis, E., Chavakis, T., von Hundelshausen, P., Köhl, J., Gawaz, M., Langer, H.F. The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nat Commun. 2021 Jun 7;12(1):3352. doi: 10.1038/s41467-021-23499-w. PMID: 34099640.

 

Dömer, D., Walther, T., Möller, S., Behnen, M., and Laskay, T. (2021) Neutrophil Extracellular Traps Activate Proinflammatory Functions of Human Neutrophils. Front. Immunol. 12:636954. doi: 10.3389/fimmu.2021.636954

 

Friščić, J., Böttcher, M., Reinwald, C., Bruns, H., Wirth, B., Popp, S.J., Walker, K.I., Ackermann, J.A., Chen, X., Turner, J., Zhu, H., Seyler, L., Euler, M., Kirchner, P., Krüger, R., Ekici, A.B., Major, T., Aust, O., Weidner, D., Fischer, A., Andes, F.T., Stanojevic, Z., Trajkovic, V., Herrmann, M., Korb-Pap, A., Wank, I., Hess, A., Winter, J., Wixler, V., Distler, J., Steiner, G., Kiener, H.P., Frey, B., Kling, L., Raza, K., Frey, S., Kleyer, A., Bäuerle, T., Hughes, T.R., Grüneboom, A., Steffen, U., Krönke, G., Croft, A.P., Filer, A., Köh,l J., Klein, K., Buckley, C.D., Schett, G., Mougiakakos, D., Hoffmann, M.H. The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts. Immunity. 2021 Mar 19:S1074-7613(21)00115-1. doi: 10.1016/j.immuni.2021.03.003. Epub ahead of print. PMID: 33761330.

 

Salyer, C. E., Bomholt, C., Beckmann, N., Bergmann, C. B., Plattner, C. A., Caldwell, C. C. Novel Therapeutics for the Treatment of Burn Infection. Surg Infect (Larchmt). 2021. 22:113-120. PMID: 32429749

 

Tackenberg, H., Möller, S., Filippi, M. D., Laskay, T. The small GTPase Cdc42 negatively regulates the formation of neutrophil extracellular traps by engaging mitochondria. Front. Immunol. 2021. 12:564720. doi: 10.3389/fimmu.2021.564720

 


  

2020

 

Jodele, S., Köhl, J. Tackling COVID-19 infection through complement-targeted immunotherapy. Br J Pharmacol. 2020. 10.1111/bph.15187. PMID: 32643798

 

Quell, K. M., Dutta, K., Korkmaz, Ü. R., Nogueira de Almeida, L., Vollbrandt, T., König, P., Lewkowich, I., Deepe, G. S. Jr., Vershoor, A., Köhl, J., Laumonnier, Y. GM-CSF and IL-33 Orchestrate Polynucleation and Polyploidy of Resident Murine Alveolar Macrophages in a Murine Model of Allergic Asthma. Int. J. Mol. Sci. 2020, 21, 7487. DOI: 10.3390/ijms21207487

 

Quäschling, T., Friedrich, D., Deepe Jr. G. S., Rupp, J. 2020. Crosstalk between autophagy and hypoxia-inducible factor-1α in antifungal immunity. Cells. 9, 2150. DOI: 10.3390/cells9102150

 

Antoniou K, Ender F, Vollbrandt T, Laumonnier Y, Rathmann F, Pasare C, Singh H, Koehl J. Allergen-Induced C5a/C5aR1 Axis Activation in Pulmonary CD11b(+) cDCs Promotes Pulmonary Tolerance through Downregulation of CD40. Cells 2020, 9(2), doi:10.3390/cells9020300

 

Ritter, K., Rousseau, J., Hölscher, C. The Role of gp130 Cytokines in Tuberculosis. Cells. 2020. 15;9(12):2695. PMID: 33334075

 

Almanan, M., Raynor, J., Ogunsulire, I., Malyshkina, A., Mukherjee, S., Hummel, S. A., Ingram, J. T., Saini, A., Xie, M. M., Alenghat, T., Way, S. S., Deepe, G. S. Jr., Divanovic, S., Singh, H., Miraldi, E., Zajac, A. J., Dent, A. L., Hölscher, C., Chougnet, C., Hildeman, D. A. IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression. Sci Adv. 2020 29;6(31):eabb0806. PMID: 32832688

 

Link, C. W. M., Rau, C. N., Udoye, C. C., Ragab, M., Korkmaz, R. Ü., Comdühr, S., Clauder, A. K., Lindemann, T., Frehse, B., Hofmann, K., Almeida, L. N., Laumonnier, Y., Beidaq, A. E., Finkelman, F. D., Manz, R. A. IL-2-Agonist-Induced IFN-γ Exacerbates Systemic Anaphylaxis in Food Allergen-Sensitized Mice. Front Immunol. 2020. 11;11:596772. PMID: 33362780

 

Tackenberg, H., Möller, S., Filippi, M. D., Laskay, T. The Small GTPase Cdc42 Is a Major Regulator of Neutrophil Effector Functions. Front Immunol. 2020. 12;11:1197. PMID: 32595647

 

Thiel, A. L., Ragab, M., Wagner, A. E., Divanovic, S., Derer, S., Sina, C. Purification and Functional Characterization of the Chloroform/Methanol-Soluble Protein 3 (CM3) From Triticum aestivum in Drosophila melanogaster. Front Nutr. 2020. 23;7:607937. PMID: 33425975

 


  

2019

 

Friedrich D, Zapf D, Lohse B, Fecher RA, Deepe GS, Rupp J. The HIF-1a/LC3-II axis impacts fungal immunity in human macrophages. Infection and Immunity 2019, 87(7), e00123-19. PMID:31036602

 

Twisselmann N, Bartsch YC, Pagel J, Wieg C, Hartz A, Ehlers M, Härtel C.  IgG Fc Glycosylation Patterns of Preterm Infants Differ With Gestational Age. Front Immunol. 2019 Jan 18; 9:3166. doi: 10.3389/fimmu.2018.03166. PMID: 30713537

 

Schröder, T., Wiese, A., Ender, F., Quell, K., Vollbrandt, T., Duhn, J., Sünderhauf, A., Künstner, A., Moreno-Fernandez, M., Derer, S., Aherrahrou, Z., Lewkowich, I., Divanovic, S., Sina, C., Köhl, J., Laumonnier, Y. Short-term high fat diet feeding protects from the development of experimental allergic asthma in mice. Clin. Exp. Allergy. 2019 49:1245-1257. PMID: 31265181

 

Kordowski, A., Reinicke, A. T., Wu, D., Orinska, Z., Hagemann, P., Huber-Lang, M., Lee, J. B., Wang, Y. H., Hogan, S. P., Köhl, J. C5a receptor 1-/- mice are protected from the development of IgE-mediated experimental food allergy. Allergy. 2019. 74(4):767-779.  PMID: 30341777

 


 

2018

 

Graspeuntner S, Waschina S, Künzel S, Twisselmann N, Rausch TK, Cloppenborg-Schmidt K, Zimmermann J, Viemann D, Herting E, Göpel W, Baines JF, Kaleta C, Rupp J, Härtel C, Pagel J. Gut dysbiosis with Bacilli dominance and accumulation of fermentation products precedes late-onset sepsis in preterm infants. Clin Infect Dis.2018 doi: 10.1093/cid/ciy882. PMID: 30329017

 

Hoffmann FM, Berger JL, Lingel I, Laumonnier Y, Lewkowich IP, Schmudde I, and König P. Distribution and interaction of Murine Pulmonary Phagocytes in the naive and allergic lung. Frontiers in Immunology, 9:1046; 2018 PMID: 29868009

 

Eresso A, Arkajyoti M, Deepti R, Vasundhara M, Tejaswini P, van Zandbergen G, Solbach W, Dandapat J, Tackenberg H, Ohms M, Sarkar A, Laskay T. Type-1 interferons prolong the lifespan of neutrophils by interfering with members of the apoptotic cascade. Cytokine,Volume 112, 2018, Pages 21-26, ISSN 1043-4666. PMID: 30554594

 

Göpel W, Drese J, Rausch TK, Twisselmann N, Bohnhorst B, Müller A, Franz A, Ziegler A, Härtel C, Herting E. Necrotizing enterocolitis and high intestinal iron uptake due to genetic variants. Pediatr Res. 2018 Jan; 83(1-1):57-62. doi: 10.1038/pr.2017.195. PMID: 28820869

 

Textor, J., Fähnrich, A., Meinhardt, M., Tune, C., Klein, S., Pagel, R., König, P., Kalies, K., Westermann, J. Deep Sequencing Reveals Transient Segregation of T Cell Repertoires in Splenic T Cell Zones during an Immune Response. J Immunol. 2018 201:350-358. PMID: 29884700

 

Klein, S., Fähnrich, A., Sergé, A., Nyhoegen, C., Kombrink, S., Möller, S., Keller, K., Westermann, J., Kalies, K. CD154 Costimulation Shifts the Local T-Cell Receptor Repertoire Not Only During Thymic Selection but Also During Peripheral T-Dependent Humoral Immune Responses. Front Immunol. 2018. 9:1019. PMID: 29867987

 

Moreno-Fernandez, M, E., Giles, D. A., Stankiewicz, T. E., Sheridan, R., Karns, R., Cappelletti, M., Lampe, K., Mukherjee, R., Sina, C., Sallese, A., Bridges, J. P., Hogan, S. P., Aronow, B. J., Hoebe, K., Divanovic, S. Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease. JCI Insight. 2018. 22;3(6):e93626. PMID: 29563328

 

Epp, A., Hobusch, J., Bartsch, Y. C., Petry, J., Lilienthal, G-M., Koeleman, C. A. M., Schweiler, S., Möbs, C., Hall, A., Morris, S. C., Braumann, D., Engellenner, C., Bitterling, J., Rahmöller, J., Leliavski, A., Thurmann, R., Collin, M., Moremen, K. W., Strait, R. T., Blanchard, V., Petersen, A., Gemoll, T., Habermann, J. K., Petersen, F., Nandy, A., Kahlert, H., Hertl, M., Wuhrer, M., Pfützner, W., Jappe, U., Finkelmann, F. D., Ehlers, M. Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions. J. Allergy Clin. Immunol. 2018. 141(1):399-402.e8. PMID: 28728998

 

Pandey, M. K., Grabowski, G. A., Köhl, J. An unexpected player in Gaucher disease: The multiple roles of complement in disease development. Semin Immunol. 2018. 37:30-42. PMID: 29478824

 

Bröker, K., Figge, J., Magnusen, A. F., Manz, R. A., Köhl, J., Karsten, C. M. A Novel Role for C5a in B-1 Cell Homeostasis. Front Immunol. 2018. 9:258. PMID: 29520270

 


  

2017

 

Li, K-P., Fahnrich, A., Roy, E, Cuda, C.M., Grimes, H.L., Perlman, H., Kalies, K., and D.A. Hildeman. Temporal expression of Bim limits the development of TCR+ double negative and CD8aa intestinal epithelial lymphocytes. J.Immunol. 2017. 198(1): 257 - 269. PMID: 27852740

 

Johnson BL 3rd, Midura EF, Prakash PS, Rice TC, Kunz N, Kalies K, Caldwell CC. Neutrophil derived microparticles increase mortality and the counter-inflammatoryresponse in a murine model of sepsis. Biochim Biophys Acta. 2017 Jan 17. pii:S0925-4439(17)30017-0. doi: 10.1016/j.bbadis.2017.01.012. [Epub ahead of print] PubMed PMID: 28108420

 

Karsten CM, Wiese AV, Mey F, Figge J, Woodruff TM, Reuter T, Scurtu O, Kordowski A, Almeida LN, Briukhovetska D, Quell KM, Sun J, Ender F, Schmudde I, Vollbrandt T, Laumonnier Y, Köhl J. Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse. J Immunol. 2017 Nov 1;199(9):3234-3248. doi: 10.4049/jimmunol.1700710. Epub 2017 Sep1. PMID: 28864475

 

Pagel, R., Bär, F., Schröder, T., Sünderhauf, A., Künstner, A., Ibrahim, S. M., Autenrieth, S. E., Kalies, K., König, P., Tsang, A. H., Bettenworth, D., Divanovic, S., Lehnert, H., Fellermann, K., Oster, H., Derer, S., Sina, C. Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine. FASEB J. 2017. 31(11):4707-4719. PMID: 28710114

 

Giles, D. A., Moreno-Fernandez, M. E., Stankiewicz, T. E., Graspeuntner, S., Cappelletti, M., Wu, D., Mukherjee, R., Chan, C. C., Lawson, M. J., Klarquist, J., Sünderhauf, A., Softic, S., Kahn, C. R., Stemmer, K., Iwakura, Y., Aronow, B. J., Karns, R., Steinbrecher, K. A., Karp, C. L., Sheridan, R., Shanmukhappa, S. K., Reynaud, D., Haslam, D. B., Sina, C., Rupp, J., Hogan, S. P., Divanovic, S.  Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling. Nat Med. 2017. 23(7):829-838. PMID: 28604704

 

Friedrich, D., Fecher, R. A., Rupp, J., Deepe, G. S. Jr. Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity. Microbes Infect. 2017. 19(3):204-209. PMID: 27810563

 

Feldhoff, L. M., Rueda, C. M., Moreno-Fernandez, M. E., Sauer, J., Jackson, C. M., Chougnet, C. A., Rupp, J. IL-1β induced HIF-1α inhibits the differentiation of human FOXP3+ T cells. Sci Rep. 2017. 7(1):465. PMID: 28352109

 

Heppe, E. N., Tofern, S., Schulze, F. S., Ishiko, A., Shimizu, A., Sina, C., Zillikens, D., Köhl, J., Goletz, S., Schmidt, E. Experimental Laminin 332 Mucous Membrane Pemphigoid Critically Involves C5aR1 and Reflects Clinical and Immunopathological Characteristics of the Human Disease. J Invest Dermatol. 2017. 137(8):1709-1718. PMID: 28456612

 

Pandey, M. K., Burrow, T. A., Rani, R., Martin, L. J., Witte, D., Setchell, K. D., Mckay, M. A., Magnusen, A. F., Zhang, W., Liou, B., Köhl, J., Grabowski, G. A. Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease. Nature. 2017. 543(7643):108-112. PMID: 28225753

 


 

2016

 

Milićević NM, Schmidt F, Kunz N, Kalies K, Milićević Ž, Schlosser A, Holmskov U, Sorensen GL, Westermann J. The role of microfibrillar-associated protein 4(MFAP4) in the formation and function of splenic compartments during embryonic and adult life. Cell Tissue Res. 2016 Jul;365(1):135-45.  PubMed PMID: 26899386

 

Pagel J, Hartz A, Figge J, Gille C, Eschweiler S, Petersen K, Schreiter L,Hammer J, Karsten CM, Friedrich D, Herting E, Göpel W, Rupp J, Härtel C. Regulatory T cell frequencies are increased in preterm infants with clinicalearly-onset sepsis. Clin Exp Immunol. 2016 Aug;185(2):219-27. PubMed PMID: 27163159

 

Hoffmann F, Ender F, Schmudde I, Lewkowich IP, Köhl J, König P, Laumonnier Y. Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma. Front Immunol. 2016 Mar 23;7:107. Review. PubMed PMID: 27047494. 

 

Midura EF, Prakash PS, Johnson BL 3rd, Rice TC, Kunz N, Caldwell CC. Impact of caspase-8 and PKA in regulating neutrophil-derived microparticle generation. Biochem Biophys Res Commun. 2016 Jan 22;469(4):917-22. PubMed PMID: 26707875

 

Moreno-Fernandez, M. E., Aliberti, J., Groeneweg, S., Köhl, J., and Chougnet, C. A. A Novel Role for the Receptor of the Complement Cleavage Fragment C5a, C5aR1, in CCR5-Mediated Entry of HIV into Macrophages. AIDS Res Hum Retroviruses 2016. 32, 399-408 PMID: 26537334

 

Fecher, R. A., Horwath, M. C., Friedrich, D., Rupp, J., and Deepe, G. S., Jr. Inverse Correlation between IL-10 and HIF-1alpha in Macrophages Infected with Histoplasma capsulatum. J. Immunol. 2016.197, 565-579 PMID: 27271565

 

Schröder, T., Kucharczyk, D., B.r, F., Pagel, R., Derer, S., Jendrek, S. T., Sunderhauf, A., Brethack, A. K., Hirose, M., Moller, S., Kunstner, A., Bischof, J., Weyers, I., Heeren, J., Koczan, D., Schmid, S. M., Divanovic, S., Giles, D. A., Adamski, J., Fellermann, K., Lehnert, H., Köhl, J., Ibrahim, S., and Sina, C. Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis. Mol. Metab. 2016. 5, 283-295 PMID: 27069868

 

Kulkarni, U., Karsten, C. M., Kohler, T., Hammerschmidt, S., Bommert, K., Tiburzy, B., Meng, L., Thieme, L., Recke, A., Ludwig, R. J., Pollok, K., Kalies, K., Bogen, B., Boettcher, M., Kamradt, T., Hauser, A. E., Langer, C., Huber-Lang, M., Finkelman, F. D., Köhl, J., Wong, D. M., and Manz, R. A. IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration. J. Allergy Clin. Immunol. 2016. 137, 1487-1497 e1486 PMID: 26653800

 

Olsson, A., Venkatasubramanian, M., Chaudhri, V., Aronow, B.J., Salomonis, N., Singh, H., Grimes, H.L. Single-cell analysis of mixed-lineage states leading to a binary cell fate choice. Nature, 2016. 537, 698 – 702 PMID: 27580035

 


 

2015 

 

Köhl J, Moreno-Fernandez ME, Aliberti J, Groeneweg S, Chougnet C. A novel rolefor the receptor of the complement cleavage fragment C5a, C5aR1, in CCR5-mediatedentry of HIV into macrophages. AIDS Res Hum Retroviruses. 2015 Nov 5. PubMed PMID: 26537334.

 

Bollinger T, Bollinger A, Gies S, Feldhoff L, Solbach W, Rupp J. Transcriptionregulates HIF-1α expression in CD4(+) T cells. Immunol Cell Biol. 2015 Jul 7. PubMed PMID: 26150319.

 

Karsten CM, Laumonnier Y, Eurich B, Ender F, Bröker K, Roy S, Czabanska A, Vollbrandt T, Figge J, Köhl J. Monitoring and Cell-Specific Deletion of C5aR1 Using a Novel Floxed GFP-C5aR1 Reporter Knock-in Mouse. J Immunol. 2015 Jan 14. pii: 1401401.PubMed PMID: 25589074

 

McCarthy MK, Procario MC, Twisselmann N, Wilkinson JE, Archambeau AJ, Michele DE, Day SM, Weinberg JB. Proinflammatory effects of interferon gamma in mouse adenovirus 1 myocarditis. J Virol.; 89(1):468-79. doi: 10.1128/JVI.02077-14. PMID: 25320326

 

Strait, R. T., Posgai, M. T., Mahler, A., Barasa, N., Jacob, C. O., Köhl, J., Ehlers, M., Stringer, K., Shanmukhappa, S. K., Witte, D., Hossain, M. M., Khodoun, M., Herr, A. B., and Finkelman, F. D. IgG1 protects against renal disease in a mouse model of cryoglobulinaemia. Nature 2015. 517, 501-504. PMID: 25363774

 


 

2014

 

Strait RT, Posgai MT, Mahler A, Barasa N, Jacob CO, Köhl J, Ehlers M, Stringer K, Shanmukappa SK, Witte D, Hossain MM, Khodoun M, Herr AB, Finkelman FD. IgG1protects against renal disease in a mouse model of cryoglobulinaemia. Nature.2014 Nov 2. PubMed PMID:25363774.

 

Engelke C, Wiese AV, Schmudde I, Ender F, Ströver HA, Vollbrandt T, König P, Laumonnier Y, Köhl J. Distinct roles of the anaphylatoxins C3a and C5a in dendritic cell-mediated allergic asthma. J Immunol. 2014 Dec 1;193(11):5387-401. PubMed PMID: 25355927.

 

Bollinger T, Gies S, Naujoks J, Feldhoff L, Bollinger A, Solbach W, Rupp J. HIF-1α- and hypoxia-dependent immune responses in human CD4+CD25high T cells and T helper 17 cells. J Leukoc Biol. 2014 Aug;96(2):305-12. PubMed PMID: 24664971

 

Berod L, Stüve P, Varela F, Behrends J, Swallow M, Kruse F, Krull F, Ghorbani P, Mayer CT, Hölscher C, Sparwasser T. Rapid rebound of the Treg compartment inDEREG mice limits the impact of Treg depletion on mycobacterial burden, butprevents autoimmunity. PLoS One. 2014 Jul 22;9(7):e102804.  PubMed PMID: 25050936.

 

Schmitz V, Almeida LN, Svensjö E, Monteiro AC, Köhl J, Scharfstein J. C5a and Bradykinin Receptor Cross-Talk Regulates Innate and Adaptive Immunity inTrypanosoma cruzi Infection. J Immunol. 2014 Oct 1;193(7):3613-23. Epub 2014 Sep 3. PubMed PMID: 25187655.

 

Bär F, Föh B, Pagel R, Schröder T, Schlichting H, Hirose M, Lemcke S, Klinger A, König P, Karsten CM, Büning J, Lehnert H, Fellermann K, Ibrahim SM, Sina C. Carboxypeptidase E modulates intestinal immune homeostasis and protects against experimental colitis in mice. PLoS One 2014. 9:1–9. PMID:25051500

 


 

2013

 

Hess C, Winkler A, Lorenz AK, Holecska V, Blanchard V, Eiglmeier S, Schoen AL, Bitterling J, Stoehr AD, Petzold D, Schommartz T, Mertes MM, Schoen CT, Tiburzy B, Herrmann A, Köhl J, Manz RA, Madaio MP, Berger M, Wardemann H, Ehlers M. T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies. J Clin Invest. 2013 Sep 3;123(9):3788-96. PMID:23979161

 

Kemper C, Köhl J. Novel roles for complement receptors in T cell regulation and beyond. Mol Immunol. 2013 Jun 21. PubMed PMID: 23796748.

 

Schmudde I, Laumonnier Y, Köhl J. Anaphylatoxins coordinate innate and adaptive immune responses in allergic asthma. Semin Immunol. 2013 May 19. PubMed PMID: 23694705.